Possible Interaction: Vitamin D and Aldesleukin

“ IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not reach significance.”

“Also, vitamin D reduces the production of inflammatory cytokines, such as IL-2 and interferon-gamma (INFγ).”

“Over the past several years Vitamin D has been recognized as a hormone with significant immunomodulatory effect due to the fact that it inhibits T-cell proliferation and decreases the production of interleukin-2 , interferon-γ, and tumor necrosis factor-α.”

“ IL-2 , Ig-A, and Ig-G levels are significant increased in the vitamin D supplementation group compared with the control group (p < .05) (3).”

“Results: PD-1 expression upon T cell stimulation was increased in CD4+CD25+int T cells in vitamin D treated CD patients from 19% (range 10 39%) to 29% (11 79%)(p = 0.03) compared with placebo-treated patients.”

“ Vitamin D has the ability to suppress inflammatory cytokines such as TNF, IL-1, IFN-gamma and IL-2 ; while it increases the generation of anti-inflammatory cytokines IL-4 and IL-10.”

“ Vitamin D has been shown to inhibit mononuclear and T lymphocyte cell proliferation by decreasing the production of IL-1beta, IL-2 , IL-6, interferon c, and TNF-alpha.”

“However, 100 nM of vitamin D3 significantly increased the release of IL-10, but suppressed the production of IL-2 , IL-6, interferon γ and TNF α in the culture supernatants of both groups.”

“Short-term cultures of primary human T cells were used to show that expression of cyclins D2 and D3 is regulated by IL-2 in a concentration- and time-dependent manner.”

“1,25-(OH)2 D3 inhibits lymphocyte proliferation, immunoglobulin production and the release of cytokines including interleukin-2 (IL-2) and interferon gamma (IFN gamma) by mitogen driven blood mononuclear cells (MNC).”