Possible Interaction: Vitamin C and Gentamicin

“Combined treatment of infected mice with gentamicin and ascorbic acid eradicated the bacteria from the blood, spleen and synovial tissue and showed a significant gross reduction in arthritis, reduced serum levels of tumour necrosis factor alpha (TNF‐α) and interferon gamma (IFN‐γ).”

“Concomitant administration of gentamicin and vitamin C resulted in a significant reduction of morphological and functional kidney alterations.”

“In view of this concept, the present in vivo study is carried out to evaluate the inhibitory effect of ascorbic acid on lipid peroxidation induced by gentamicin , an aminoglycoside antibiotic.”

“However, vitamins C and E given concurrently with gentamicin completely abrogated this enzymatic suppression.”

“In the gentamicin plus vitamin C group , the renal tissue Mn-SOD activity was found to be higher as compared with control and gentamicin groups.”

“Sulfhydryl compounds (glutathione, dithioerythritol) and antioxidants vitamin C , phenylene diamine, trolox) prevented the cytotoxic actions of the gentamicin metabolite.”

“DFO and in particular DFO + AA lowered the MICs of cephalothin, gentamicin , cefotaxime, and fusidic acid for most of the strains and in some instances also the MICs of vancomycin.”