Possible Interaction: Vitamin C and Ferric Ion

“ Ascorbic acid reduces transition metals such as ferric ion to ferrous ion and generates hydrogen peroxide and free radicals via Fenton chemistry.”

“The ferric iron is reduced by ascorbic acid producing ferrous iron which is coupled with α,α′-dipyridyl.”

“It is believed that vitamin C can reduce both ferric (Fe3+) and ferrous (Fe2+) ions, and also facilitate the accessibility of iron to chelators through increase of iron release from the reticuloendothelial system.”

“Ferric iron in a 2:1 Fe/Zn ratio reduced the plasma uptake of zinc, but to a significantly lesser degree than ferrous iron; addition of 1 g of ascorbic acid increased the magnitude of the inhibitory effect of ferric iron to that seen with ferrous iron.”

“Its capacity for reducing ferric ion was more than ascorbic acid.”

“Physiological concentrations of ascorbic acid continuously provided by red blood cells probably rereduces Fe(III)P , leading to the apparent long lifetime of the dioxygenated species of FeP.”

“ Fe++ and a number of other heavy metal ions, as well as dipyridyl, lipoic acid, CoA—SH, and H2O2 generated in situ strongly inhibit it, whereas ascorbic acid , imidazole, aminopterin, and folic acid have little or no effect.”

“ Ascorbic acid can reduce both Fe(III) to Fe(II) and As(III) to As0.”

“The addition of AA accelerated the transformation of Fe(III) to Fe(II), and the complexation of Fe(III)/Fe(II) with AA and its products alleviated the precipitation of dissolved iron.”

“The presence of ascorbic acid could relieve the accumulation of Fe(III) by reductive accelerating the Fe(III)/Fe(II) cycles, as well as lower the redox potential of Fe(III)/Fe(II) through chelating effect, leading to enhanced ROS generation for promoting RhB degradation.”