Possible Interaction: Vitamin C and Calcium Supplement

“It was concluded that (1) under normal conditions an abettor role of ASC for renal stones is not recognizable, (2) in … exogenous ASC is exhibited, and that this is most likely unrelated to an initial increase in oxalate biosynthesis, and (3) ASC … calcium oxalate crystallization in … still not known.”

“During intervention, calcium, magnesium, phosphorus, potassium, thiamin, riboflavin, and vitamins C and D increased (P < 0.01) in the group receiving food calcium but not in the placebo or supplement groups.”

“In the initiation, and second, stages of the reaction, the property of ascorbic acid to chelate with calcium appears to play an importnat role in the ultimate release of the mediators.”

“ AA at a 2:1 or 4:1 molar ratio enhanced iron absorption by a factor of 2-4 and greatly overcompensated for the inhibitory effect of calcium on iron absorption in a dose-dependent manner (P < 0.001).”

“The combination of calcium plus vitamin C did not reduce vertebral fracture risk, but did reduce nonvertebral fracture risk in certain populations.”

“Of major concern has been the influence of ingesting gram amounts of ascorbic acid on renal calcium oxalate stones, systemic conditioning, uricosuria, vitamin B12 destruction, mutagenicity, and iron overload.”

“ Ascorbic acid increased the calcium blocking effect of NP but did not influence the inhibitory effect of GTN.”

“Of major concern has been the influence of ingesting gram amounts of ascorbic acid on renal calcium oxalate stones, systemic conditioning, uricosuria, vitamin B12 destruction, mutagenicity, and iron overload.”

“The results suggest that ascorbic acid has a short-term effect on the regulation of the absorption and metabolism of calcium in humans.”

“ Calcium ions also increased ascorbic acid absorption probably by a secondary effect on "Na+ fluxes.”