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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Vitamin B 6 and Pimagedine

supplement:

Vitamin B 6

Research Papers that Mention the Interaction

Aminoguanidine improved the erythrocyte filterability by 4%, pyridoxyliden-aminoguanidine by 11% and pyridoxal by 13% in healthy subjects.
Bratislavske lekarske listy  •  2003  |  View Paper
Further, they affect bone mechanical properties and microdamage accumulation, and can be inhibited in vitro by various inhibitors and breakers (e.g. aminoguanidine , N-Phenacylthiazolium Bromide, vitamin B6).
Bone  •  2016  |  View Paper
AG dramatically decreased the pyridoxal phosphate level in the diabetic rat liver, whereas PL-AG only moderately affected it.
Free radical biology & medicine  •  2003  |  View Paper
However, administration of aminoguanidine decreases the hepatic content of pyridoxal phosphate.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2002  |  View Paper
AG reacted in vitro far more rapidly with PLP to form a Schiff base (PLP-AG) than with PL to form another Schiff base (PL-AG).
Simultaneous administration of pyridoxine (1 mM in drinking water) with AG (7 mM in drinking water) did not ameliorate the decrease in tissue PLP and caused the excess formation of PLP-AG.
The amount of PLP in the liver of mice AG administered was significantly lower than that of control mice (4.0 +/- 1.4 vs 17.4 +/- 1.3 nmol/g of wet tissue, mean +/- SD, N = 6).
Biochemical pharmacology  •  1998  |  View Paper
AG was found to inhibit not only glycation of albumin but binding of PLP to albumin, indicating that distribution of PLP into tissues is inhibited by AG.
Journal of nutritional science and vitaminology  •  1995  |  View Paper