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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin B 6
drug:
Pimagedine
Research Papers that Mention the Interaction
“ Aminoguanidine improved the erythrocyte filterability by 4%, pyridoxyliden-aminoguanidine by 11% and pyridoxal by 13% in healthy subjects.”
The effect of selected membrane active substances on erythrocyte deformability.“Further, they affect bone mechanical properties and microdamage accumulation, and can be inhibited in vitro by various inhibitors and breakers (e.g. aminoguanidine , N-Phenacylthiazolium Bromide, vitamin B6).”
“ AG dramatically decreased the pyridoxal phosphate level in the diabetic rat liver, whereas PL-AG only moderately affected it.”
Antioxidant activity of a Schiff base of pyridoxal and aminoguanidine.“However, administration of aminoguanidine decreases the hepatic content of pyridoxal phosphate.”
“ AG reacted in vitro far more rapidly with PLP to form a Schiff base (PLP-AG) than with PL to form another Schiff base (PL-AG).”
“Simultaneous administration of pyridoxine (1 mM in drinking water) with AG (7 mM in drinking water) did not ameliorate the decrease in tissue PLP and caused the excess formation of PLP-AG.”
“The amount of PLP in the liver of mice AG administered was significantly lower than that of control mice (4.0 +/- 1.4 vs 17.4 +/- 1.3 nmol/g of wet tissue, mean +/- SD, N = 6).”
“ AG was found to inhibit not only glycation of albumin but binding of PLP to albumin, indicating that distribution of PLP into tissues is inhibited by AG.”
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