Possible Interaction: Vitamin B 6 and Multivitamin Preparation

“…:Multivitamin treatment significantly increased (p<0.01, compared …/L), E (27 to 32 μmol/L), pyridoxal phosphate (55.1 to 75.2 nmol/L), folate (23 to 33 nmol/L), B12 (286 to … improved the riboflavin activity coefficient (1.23 to 1.15), but not vitamins A and thiamin.”

“It is suggested that pyridoxine in multivitamin preparations must exceed 1 mg to produce any useful improvement in vitamin B6 status of adolescents on suboptimal vitamin B6 intakes.”

“ Vitamin supplements produced significant improvement in pre-existing deficiencies of riboflavin, pyridoxine and folic acid.”

“Statistically significant interaction effects were observed between multivitamin use and vitamin B6 intake on myocardial infarction, between multivitamin use and vitamin D intake on CVD mortality, and between multivitamin use and vitamin B12 intake on CVD mortality and total mortality.”

“Excretion of group B vitamins (especially vitamin B6 , 1.75 fold, p < 0.05) in women taking vitamin supplements was higher compared to non-taking vitamins that indicates the better sufficiency of the organism with these vitamins.”

“Conclusions: Dietary intake of VB6 was associated with a reduced risk of coronary heart disease among middle-aged non-multivitamin supplement users.”

“ Black multivitamin users had higher concentrations of vitamin B6 (53.7 vs. 29.5 nmol/L; p < 0.001), B12 (427 vs. 372 pmol/L; p < 0.05) and folate (35.7 vs. 25.4 nmol/L; < 0.001) than non-users.”

“Use of low doses of pyridoxine in multivitamin supplements could be a confounding factor for early diagnosis and appropriate treatment of pyridoxine‐dependent seizures.”

“The estimated B6 intakes and plasma pyridoxal phosphate levels of children who took vitamin supplements were significantly higher than values for subjects not taking supplements.”