Possible Interaction: Vitamin B 6 and Folate

“ Vitamin B6 and B12 supplementation did not change their homocysteine levels, but folate supplementation caused a 53% reduction (to 5.7 + 1.6).”

“A dose-… between folate … vitamin B-6 intake and the risk of stroke, with a pooled RR of 0.94 (95% CI: 0.90–0.98) and 0.…) for each 100 μg/d increment in folate intake and 0.5 mg/d increment in vitamin B-6 intake, respectively.”

“We found that dietary intake of vitamin B-6 and folate were associated with a reduced risk of stroke, and this inverse association remained significant in studies with >10 y of follow-up periods and among participants without a pre-existing stroke event.”

“From 21 articles reporting 26 studies including 6404 EC cases and 504,550 controls, we found an inverse correlation between the consumption of vitamin B6 and folate and the risk of EC; this association was specific to the US, Europe, and Australia, but was not found in Asia.”

“A composite score (range from 2 to 8), reflecting combined dietary intake of folate and vitamin B6 , was also inversely associated with pancreatic cancer risk [OR (95% CI) for Q4 vs. Q1: 0.24 (0.08–0.70)].”

“ConclusionsDietary folate intake was associated with a reduced pancreatic cancer risk, and this association became stronger when dietary intake of folate and vitamin B6 was combined in analysis.”

“A nonlinear dose-response meta-analysis demonstrated a linear inverse association between folate and vitamin B6 intake and risk of CHD.”

“Recent studies suggest inverse associations between folate and vitamin B6 intakes and colorectal cancer risk but associations with other B vitamins and methionine have not been widely studied.”

“Serum concentrations HDL-cholwere increased significantly (from42 ± 10 mg/dL to 47 ± 10 mg/dL, p < 0.001).The atherogenic index for … drugs receiving(before: LDL/HDL = 3.1 and after: LDL/HDL = 2.5,p < 0.001).Conclusions: These results indicate thatthe folate … vitamin B6 supplementationresulted in … patients.”

“The risk of spontaneous abortion … suboptimal plasma concentrations of both folate … vitamin B6 (folate less than or equal to 8.4 nmol/L and vitamin B6 less than or equal to … with higher plasma concentrations of both vitamins (odds ratio 4.1, 95% confidence interval 1.2, 14.4).”

“Recent studies focussing on the reduction of plasma homocysteine as a risk factor for vascular disease showed that vitamin B6 reduces plasma folate levels.”

“01) and red-cell (P < 0.05) folate were significantly higher, and vitamin B6 concentrations appeared to be significantly lower (P < 0.”