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“CONCLUSIONS Adults with pediatric-onset HPP receiving as otase alfa at 6.0 mg/kg/wk (the recommended dose) or 9.0 mg/kg/wk had greater reductions in circulating PPi and PLP co ncentrations compared with a lower dose of 1.5 mg/kg/wk.”
“However, for the total cohort, the within subject changes in both PLP and PPi after 6 months and over 5 years of treatment with asfotase alfa were significant (P < 0.05).”