Possible Interaction: Vitamin B 12 and Multivitamin Preparation

“Excessive vitamin B12 and multivitamin supplementation should be avoided by choosing supplement wisely.”

“Patients with multivitamin usage had a lower rate of iron deficiency (26% vs. 56%, p = 0.034), vitamin B12 (11% vs. 25%, p = 0.46) and vitamin D (46% vs. 75%, p = 0.07), compared to non-compliant patients.”

“In linear regression analysis, the use of individual vitamin B-12 supplements … = 0.263; P = 0.024; R2 = 0.069), the use of a multivitamin … vitamin B-12 concentrations (β ± SE -222.0 ± 98.7; standardized β = -0.258; … predictive of vitamin B-12 milk concentration (P > 0.05).”

“Among metformin users, multivitamin use was associated with lower prevalence of combined low and borderline vitamin B12 concentrations (aOR = 0.14; 95% CI = 0.04, 0.54) compared to those not using multivitamins.”

“Among the participants with diabetes who were on metformin therapy, multivitamin use was associated with geometric mean serum vitamin B12 concentrations that were 50% (or 161 pmol/L) higher, compared to those not using multivitamins.”

“Subjects consuming vitamin supplements (n=62) had significantly higher plasma vitamin B12 levels, lower MMA levels and lower Hcy levels.”

“Individuals in both groups who used multivitamin supplements had significantly higher biochemical values for thiamine (p less than 0.03), riboflavin (p less than 0.01), and vitamin B-12 (p less than 0.003) than nonsupplement users.”