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“ Cyanocobalamin [c-lactam] prevented utilization of the methyl group of methylfolate , but no evidence of folate deficiency developed in long-term culture.”
“We conclude that cobalamin inactivation decreases purine synthesis by both methylfolate trapping and reduction of intracellular methionine synthesis.”
The Journal of clinical investigation • 1985 | View Paper
“Enzyme-bound cob(I)alamin was shown to react very rapidly with methyltetrahydrofolate (with an observed rate constant of 250 s-1 versus a turnover number under maximal velocity conditions of 19 s-1).(ABSTRACT TRUNCATED AT 250 WORDS)”