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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Vitamin B 12 and Levomefolate

supplement:

Vitamin B 12

supplement:

Levomefolate

Research Papers that Mention the Interaction

Cyanocobalamin [c-lactam] prevented utilization of the methyl group of methylfolate , but no evidence of folate deficiency developed in long-term culture.
Leukemia & lymphoma  •  1998  |  View Paper
We conclude that cobalamin inactivation decreases purine synthesis by both methylfolate trapping and reduction of intracellular methionine synthesis.
The Journal of clinical investigation  •  1985  |  View Paper
Enzyme-bound cob(I)alamin was shown to react very rapidly with methyltetrahydrofolate (with an observed rate constant of 250 s-1 versus a turnover number under maximal velocity conditions of 19 s-1).(ABSTRACT TRUNCATED AT 250 WORDS)
Biochemistry  •  1990  |  View Paper