Possible Interaction: Vitamin B 12 and Iron, Dietary

“Combined deficiencies of iron and cobalamin are common.”

“There was a significant rise in haemoglobin concentration when the anaemic individuals took iron with vitamin B12 and folic acid supplement for three consecutive months supported by two doses of anthelminthic drug.”

“It is thought valid to discontinue iron preparations prior to vitamin B12 therapy and to start them again upon the arising reticulocytic crisis.”

“Simultaneous deficiencies of cobalamin and iron , however, may be a more common cause of combined-deficiency anemia.”

“There were significant correlations between total liver reserves of vitamin B12 and iron (r = 0.742, p < 0.001), vitamin B12 and copper (r = 0.444, p < 0.001), and iron and copper (r = 0.431, p < 0.001).”

“With a combined therapy of iron , folic acid and vitamin B12 an increase of the Hb-level could be noticed at only 44.3% of the patients.”

“Initially there were no significant differences between the groups (P > 0.4), but after treatment with iron and vitamin B12 for 3 and 6 weeks, the glycosylated haemoglobin concentration decreased significantly (P < 0.01).”

“Consistently, exogenous supplement of iron and VB12 greatly improved the anemia phenotype of MCPIP1-/- mice.”

“Here we show that cobalamin (vitamin B12) and iron availability can simultaneously limit phytoplankton growth in late Austral summer coastal Antarctic sea ice edge communities.”

“A rapid B12 uptake rate was observed after 13 min, which then decreased to a slower constant uptake rate over the next … this study highlight the importance of iron availability in limiting early season Ross Sea phytoplankton growth and suggest that rates of vitamin B12 production and … by iron ….”