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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin B 12
drug:
Hypochlorite
Research Papers that Mention the Interaction
“Recently, we have highlighted the ability of HOCl to mediate the destruction of the metal‐ion derivatives of tetrapyrrole macrocyclic rings such as hemoproteins and vitamin B12 (VB12) derivatives.”
“In this report, we demonstrate that although Cobl can be an excellent antioxidant, exposure to high levels of HOCl can overcome the beneficial effects of Cobl and generate proinflammatory reaction products.”
“Our current findings extend this work and show the ability of HOCl to mediate the destruction of metal-ion derivatives of tetrapyrrole macrocyclic rings, such as cyanocobalamin (Cobl), a common pharmacological form of vitamin B12.”
The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chloride.“Food additives, such as hypochlorous acid water , sodium metabisulfite, and sodium sulfite, strongly affect the chemical and biological properties of vitamin B12 (cyanocobalamin) in aqueous solution.”
“When cyanocobalamin (10 μmol/L) was treated with these compounds, hypochlorous acid water (an effective chlorine concentration of 30 ppm) rapidly reacted with cyanocobalamin.”
Food Additives (Hypochlorous Acid Water, Sodium Metabisulfite, and Sodium Sulfite) Strongly Affect the Chemical and Biological Properties of Vitamin B12 in Aqueous Solution
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