Possible Interaction: Vitamin B 12 and Folate

“In CF children, 5-MTHF and vitamin B12 supplementation (i) increased plasma and RBC folate levels; (ii) decreased plasma homocysteine levels; (iii) modified RBC membrane phospholipid fatty acid composition; (iv) increased RBC K+ content; (v) reduced RBC membrane oxidative damage and HSP70 membrane association.”

“ Methyl cobalamin and folate interact at this critical step.”

“ Vitamin B12 and folate combined deficiency impairs fatty acid oxidation and energy metabolism in liver and heart through epigenomic mechanisms related to imbalanced acetylation/methylation.”

“In addition, fortification of food with folate and treatment of low vitamin-B12 concentrations may have masked the effect of treatment on stroke risk.”

“In ovo-lacto vegetarians, the RBC folate concentration was positively related to the intake of vitamin B-12 (r = 0.51, P: < 0.0001).”

“Patients treated with vitamin B12 and folate had a significant decrease in plasma Hcy levels (P < 0.001).”

“Unlike entacapone, combination supplementation with vitamin B12 and folate was associated with significantly decreased plasma Hcy.”

“Dietary … of folate and cobalamin showed a significant inverse correlation with plasma ANG-1 and ANG-2 (P < 0.05), particularly in subjects with estrogen-receptor positive tumors or low plasma VEGF-C. Plasma folate was positively associated with the ratio of ANG-1/ANG-2 (P < 0.05).”

“Coexisting deficiencies of folate and vitamin B12 are associated with cognitive decline, depression and neuropathy.”

“However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.”

“Also, low vitamin B-12 reduces the formation of metabolically active folate.”