Possible Interaction: Vitamin A and Vitamin C

“Adding vitamin A or E counteracts the effect of ascorbic acid in inhibiting PMP22 expression.”

“… vitamin A …], vitamin C intake with IL-1β [R = -0.25], zinc intake with PGE2 [R = -0.30], IL-2 [R = -0.23], and the activity of …], IL-1β [R = -0.23] and IL-2 [R = -0.25], and selenium intake with PGE2 [R = -0.21] (P < 0.05).”

“Conclusions: We demonstrate for the first time the synergistic interference of ascorbic acid and retinol on the measurement of uric acid in plasma.”

“Results: Among the different combinations of vitamins tested, only retinol potentiated the antioxidant effect of ascorbic acid.”

“We established that ascorbic acid interference is potentiated by regeneration of reduced ascorbic acid by retinol.”

“ Vitamin C and methionine have been found to reduce the toxicity of arsenicosis'l-', Retinoids or vitamin A is associated with clinical regression of the disease, but vitamin E has been found to potentiate the protective effect of vitamin A against the toxicity.”

“A combination of vitamins C and E (ascorbic acid, tocopherol) or solitary supplementation with vitamin A (retinoic acid) prevented lipid-peroxidation.”

“A further increase in vitamin A intubation had an adverse effect on ascorbic acid concentrations in the plasma and brain.”

“Moderate amounts of vitamin A intubation increased ascorbic acid concentration in the liver, kidney, brain and plasma.”

“Further study revealed that ascorbic acid reduced MTT to formazan, which was profoundly increased by a very small amount of retinol , whereas retinol alone had no effect.”

“ Vitamin A decreased DNA adduct levels by 70% and Vitamin C by 90% in kidney.”

“A hitherto unknown synergism exerted by retinol (vitamin A) and L-ascorbic acid (vitamin C) was discovered using endothelial cells.”

“…)ascorbic acid … vitamin A ; (b) ascorbic acid in the diet prevented or blocked the decrease in liver ascorbic acid in vitamin A deficiency but not at the …, and (d) ascorbic acid had no inhibitory effect on cholesterol synthesis and no interaction between retinyl acetate and ascorbic acid was observed.”