Possible Interaction: Vitamin A and Multivitamin Preparation

“Adding vitamin A to the multivitamin regimen reduced the benefit with regard to some of the end points examined.”

“In the Tanzanian trial [9], vitamin A supplementation alone did not show any benefit for maternal and neonatal indicators, whereas it was the case for supplementation with multiple vitamins.”

“ Vitamin A should be excluded from multivitamin supplements and food fortificants.”

“Several studies have been undertaken to assess whether vitamin A supplementation beyond that routinely given in multivitamin preparations can reduce the incidence of this outcome.”

“Self-reported multivitamin users had significantly higher concentrations of retinol (P < .001), β-carotene (P = .02), and α-tocopherol (P < .001).”

“Consumption of just one multivitamin often provides excessive vitamin A , the majority of it as preformed vitamin A esters.”

“ Vitamin A consumption by many Americans is quite high, in part because of the consumption of fortified foods and the use of vitamin supplements.”

“The amounts of retinol in fortified foods and vitamin supplements may need to be reassessed.”

“Several studies have been undertaken to assess whether vitamin A supplementation beyond that routinely given in multivitamin preparations can reduce the incidence of this outcome.”

“… vitamin A supplementation on maternal infection, and therefore on vertical transmission, could be through increasing HIV repli~ation.~ Preliminary findings from a trial in Tanzania … or no supplementation in pregnancy showed a 40% reduction in fetal death and a reduction in adverse pregnancy outcome among the women taking multivitamins ….”

“Several studies have been undertaken to assess whether vitamin A supplementation beyond that routinely given in multivitamin preparations can reduce the incidence of this outcome.”