Possible Interaction: Vitamin A and Leptin

“Supplementation with zinc, vitamin A and fish oil is associated with a significant increase in leptin levels and a significant decrease in TNF-alpha levels among children treated for TB.”

“Supplementation with vitamin A in vitro and in animal models has been found to reduce concentrations of adipocytokines, such as leptin and resistin.”

“Retinoic acid (RA) administration and chronic vitamin A supplementation were reported to inhibit adipose tissue leptin expression in rodents, but the impact of this effect on food intake and its relationship with changes of body adiposity was not analyzed.”

“The results show that vitamin A down-regulates leptin expression in white and brown adipose tissue and circulating leptin levels independently of changes of adipose tissue mass and, for the first time to our knowledge, that this effect does not correlate with increased food intake.”

“Adipose leptin mRNA levels were down regulated after vitamin A supplementation, independently of the fat content of the diet.”

“Dietary vitamin A supplementation increased UCP1 gene expression in BAT by 31%, but suppressed leptin gene expression by 44% and serum leptin levels by 65%.”

“ Retinol has negative correlations (p<0.01) with insulin and leptin.”

“The results indicated that VitA and VitE significantly reduced the levels of leptin , TNF-α, IL-6 and CRP and the ESR and significantly increased the levels of IL-10 compared with those of the model group.”