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Possible Interaction: Vitamin A and Fenretinide


Vitamin A

Research Papers that Mention the Interaction

Although fenretinide is well tolerated even after prolonged use, it does lower plasma retinol levels and thus may affect night vision.
Journal of the National Cancer Institute  •  1994  |  View Paper
We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.
Archives of ophthalmology  •  1986  |  View Paper
Although retinol and 4HPR cross-competed for RBP binding, N-phenylretinamide, in which the 4-hydroxyl group is absent, and N-(4-methoxyphenyl)retinamide, a major cellular metabolite of 4HPR, in which the hydroxyl group is blocked, did not show affinity for the binding protein.
Carcinogenesis  •  1995  |  View Paper
We show that retinol increases the affinity of RBP4 for TTR by a factor of 4 and determine the affinity constants of fenretinide and retinyl acetate.
Analytical biochemistry  •  2009  |  View Paper
Fenretinide is a synthetic retinoid that interferes with the attachment of retinol to retinol binding protein.
Documenta Ophthalmologica  •  2008  |  View Paper
Administration of the synthetic retinoid Fenretinide lowers circulating retinol and may thus affect night vision.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology  •  1994  |  View Paper
We have demonstrated, in animals and humans, that fenretinide induces a rapid reduction of retinol plasma concentration, that its blood levels remain constant during administration for as long as 5 years, and that the drug is able to accumulate in the human breast.
Cancer research  •  1994  |  View Paper
The tissue … of [3H]retinol increased by 50-130% following addition of 1.3 microM of all-trans-retinoic acid, 13-cis-retinoic acid, or …,4-didehydroretinoic acid (putative metabolites of retinol), and by 13-55% after addition of acitretin, arotenoid Ro 13-7410, or 4-(N-hydroxyphenyl)retinamide.
Skin pharmacology : the official journal of the Skin Pharmacology Society  •  1991  |  View Paper
4HPR has recently been shown to induce a decrease of retinol and retinol binding protein (RBP) plasma levels in rats and humans (5, 6).
The International journal of biological markers  •  1990  |  View Paper
The ocular side effects of fenretinide , which resemble those of other synthetic retinoids (7), may be-due to the interference of these agents with vitamin A metabolism.
Journal of the National Cancer Institute  •  1990  |  View Paper
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