Possible Interaction: Vitamin A and Doxorubicin Hydrochloride

“ DOX drastically increased lymphocyte DNA damage, liver biomarkers of protein and lipid oxidation, and mitochondrial ROS content and markedly decreased plasma retinol level, liver antioxidant enzymes, and mitochondrial functionality.”

“These rats demonstrated enhanced erythrocyte membrane lipid peroxidation (LPO) and an onslaught in the … defence armoury, witnessed by lowered activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), vitamin A , vitamin C and vitamin E. Rats administered with ADR showed a marked decline in the activities of membrane-bound ATPases.”

“Animals treated with the medium dose of VA (15 microg/kg body wt) plus single dose of DXR presented a statistically significant reduction in total number of CA and in number of abnormal metaphases (P < 0.05).”

“ ADR injected rats showed a significant decline in the activities of enzymic antioxidants (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase) and non-enzymic antioxidants (reduced glutathione, Vitamin A , Vitamin C and Vitamin E) with high malondialdehyde levels.”

“A survival study, carried out by injecting rats with a single injection of 10 mg/kg of doxorubicin , showed that pretreatment with 25 I.U. of vitamin A per kg significantly increased survival rate of the animals.(ABSTRACT TRUNCATED AT 250 WORDS)”

“The peroxyl radical-scavenging activity of vitamin A has been exploited to obtain protection against peroxidative damages induced in rat heart by administration of an acute dose of doxorubicin (10 mg/kg, in vein).”