“Activation of the latent … number of compounds influence collagenase synthesis in these cell~.l-~ Cytokines such as interleukin-la and +, tumor necrosis factor-a, polypeptide growth factors such as … phorbol esters increase MMP-1 synthesis, whereas compounds such as transforming growth factor+ (TGF-P), glucocorticoid hormones, and vitamin A ….’””