Possible Interaction: Vincristine and Gamma-Linolenic Acid

“The cell viability … results showed that GLA at 10 microg/ml enhanced cell growth inhibition … by the MDR-type drugs doxorubicin, etoposide and vincristine , but could not enhance or even attenuated cell growth inhibition induced by the non-MDR-type drug cisplatin, mitomycin and fluorouracil in K562/ADM cells.”

“In our study, it was noted that 7-1inolenic acid GLA ) and eicosapentaenoic acid (EPA) potentiated the cytotoxicity of anticancer drugs vincristine , cis-platinum, and doxorubicin on human cervical carcinoma cells in vitro by enhancing the uptake of anticancer drugs.”

“When VCR was added simultaneously with GLA or DHA to culture medium, the cytotoxic effect of VCR was about 2-fold enhanced, accompanied by about 1.5-2.0-fold increase of intracellular [3H]-VCR in both cell lines.”

“The cytotoxic effect of Vinca alkaloids such as vincristine (VCR), vindesine (VDS) and vinblastine (VBL) was about 2-fold enhanced when GLA was added simultaneously to the growth medium.”

“Alpha-linolenic acid (ALA), GLA , EPA and docosahexaenoic acid (DHA) enhanced the uptake of vincristine by HeLa cells.”

“ GLA , DGLA, AA, EPA and DHA enhanced the uptake and inhibited the efflux of vincristine and thus, augmented the intracellular concentration of the anti-cancer drug(s).”

“Gamma-linolenic acid GLA ) of the n-6 series and eicosapentaenoic acid (EPA) of the n-3 series potentiated the cytotoxicity of anti-cancer drugs: vincristine , cis-platinum and doxorubicin on human cervical carcinoma (HeLa) cells in vitro.”