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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Vincristine and Dolastatin 10

supplement:

Dolastatin 10

Research Papers that Mention the Interaction

Dolastatin 10 noncompetitively inhibits the binding of vincristine to tubulin, inhibits nucleotide exchange, stabilizes the colchicine binding activity of tubulin, and inhibits tubulin-dependent GTP hydrolysis (Bai et al., Biochem Pharmacol 39: 1941-1949, 1990; Bai et al. J Biol Chem 265: 17141-17149, 1990).
Biochemical pharmacology  •  1992  |  View Paper