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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Vinblastine
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“It was found that the resistance level of V160 to vinblastine can be increased by iron whereas resistance to both rhodamine 123 and pentamidine can be increased by iron depletion and vice versa.”
The role of Leishmania enriettii multidrug resistance protein 1 (LeMDR1) in mediating drug resistance is iron-dependent.“ Vinblastine , which attacks proliferating cells more sensitively than nonproliferating cells, lowered 59 Fe uptake severely at 24 and 48 hr, slightly at 72 hr, and not at all at 96 hr.”
“Colchicine, vinblastine , vincristine, strychnine, and heavy water, which inhibit microtubule function, all diminished transferrin and iron uptake by the cells.”
“ Vinblastine was also shown to inhibit transferrin release fiom reticulocytes and the uptake of both citrate‐bound iron and leucine.”
“ VLB has only little effect on numbers of bone marrow reticulocytes but reduces their rate of incorporation of iron.”
“ VLB leads to a complete elimination of 59 Fe uptake at 2 days but an overshoot to above normal levels at 5 days.”
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