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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Vinblastine
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“ Glutamic acid which inhibits the effect of VLB in tissue culture does not protect the rat fetus from its teratogenic effect.”
THE TERATOGENIC EFFECT OF VINCALEUKOBLASTINE IN THE PREGNANT RAT.“ Glutamic acid in laboratory and clinical investigations in the early 1960s was found to antagonize vinblastine , another clinically useful vinca alkaloid.”
Glutamic acid modification of vincristine toxicity.“Cells harvested from mice treated 2–13 h before sacrifice with vinblastine (2 mg/kg) exhibited a reduced rate of uptake of [ 14 C]glutamic acid into the acid-soluble fraction.”
“Some reduction in the amount of [ 14 C]glutamic acid entering cellular proteins was also observed after treatment with vinblastine both in vivo and in vitro .”
“Mortality from lethal doses of VLB could be reduced by administration of glutamic and aspartic acids, but this protection could not be related to any effect upon alleviation of peripheral leukopenia, decrease in packed cell volume (hematocrit), or reduction of weight loss.”
“The effect of VLB in producing metaphase arrest could be modified by the administration of glutamic acid or tryptophan.”
The effect of vincaleukoblastine on dividing cells in vivo.
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