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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Vinblastine
supplement:
Dolastatin 10
Research Papers that Mention the Interaction
“Both agents were very potent … of cell growth, with dolastatin 10 being an average of 9.1-fold more potent than dolastatin 15 [mean 50% inhibitory concentrations (IC50 values) 2.3×10–10 and 2.1×10–9M, respectively; P <0.05] and more potent than paclitaxel or vinblastine.”
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay“Of peptides that strongly inhibit tubulin polymerization (dolastatin 10, dolastatin 10 isomers, segments, … 15, and phomopsin A), only those previously shown to be strong inhibitors of vinblastine binding and nucleotide … inhibited [3H]dolastatin 10 binding and induced tubulin aggregation (dolastatin 10 itself, … isomers of dolastatin 10, and phomopsin A).”
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.
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