Possible Interaction: Vinblastine and Calcium Supplement

“CA also modulated the expression of genes associated with intrinsic pathway of apoptosis (Bcl‐2, Bax, Bak, and p53) and also … associated with inflammation such as COX‐2 and NF‐κB. Xenograft studies with SJRH30 tumors in nude mice showed that CA treatment inhibited … and without VBL and … significantly.”

“ CA in combination with VBL and CP induced a higher percentage of apoptosis than single agents in both cell lines.”

“ CA showed synergistic cytotoxic effects with vinblastine (VBL) and cyclophosphamide (CP) as indicated by the combination index values of <1 for VBL + CA, CP + CA, and VBL + CP + CA combinations in both embryonal and alveolar rhabdomyosarcomas.”

“When lower doses of CA (0.1–0.2 µg/ml) were combined with cancer drugs like CP and VBL , caspase‐3 activity increased significantly compared with individual agents and correlated with the percentage of apoptotic cells.”

“The ionophore mediated entry of Ca++ into erythrocytes potentiates primaquine endocytosis, inhibits vinblastine endocytosis, and has no regular effect on chlorpromazine endocytosis.”

“When vinblastine was administered (10 mg/kg iv), Ca++ decreased to 4.2 ± 0.07 mg/100 ml and PTH rose to 257 ± 50 pg/ml.”