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Last Updated: 2 years ago

Possible Interaction: Verapamil and Naringin

supplement:

Naringin

Research Papers that Mention the Interaction

Additionally, the efflux of paeoniflorin and naringin were apparently reduced in the presence of P-gp inhibitor verapamil.
Xenobiotica; the fate of foreign compounds in biological systems  •  2017  |  View Paper
Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement.
Compared with the control group (given verapamil alone), the Ka, Cmax and AUC of verapamil were significantly (p<0.05 or p<0.01) increased in the pretreatment of naringin , However there were no significant change in Tmax and t1/2 of verapamil.
Consequently, pretreatment of naringin significantly (p<0.05, p<0.01) increased the AB% of verapamil significantly in a dose dependent manner (p<0.05 or p<0.01), and elevated the RB% of verapamil by 1.26- to 1.69-fold.
In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil.
Naringin pretreatment significantly altered the pharmacokinetic parameters of verapamil.
the MR of verapamil were significantly (p<0.05) increased in the pretreatment of naringin , implying that pretreatment of naringin may effectively inhibit the CYP3A4-mediated metabolism of verapamil.
Archives of pharmacal research  •  2006  |  View Paper
The above data suggested that the metabolism of verapamil and the formation of norverapamil was inhibited by naringin possibly by inhibition of CYP3A in rabbits.
With naringin , the AUC of verapamil was significantly greater (28.4 versus 18.4 microg min/ml).
Biopharmaceutics & drug disposition  •  2005  |  View Paper