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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Additionally, the efflux of paeoniflorin and naringin were apparently reduced in the presence of P-gp inhibitor verapamil.”
The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model“Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement.”
“Compared with the control group (given verapamil alone), the Ka, Cmax and AUC of verapamil were significantly (p<0.05 or p<0.01) increased in the pretreatment of naringin , However there were no significant change in Tmax and t1/2 of verapamil.”
“Consequently, pretreatment of naringin significantly (p<0.05, p<0.01) increased the AB% of verapamil significantly in a dose dependent manner (p<0.05 or p<0.01), and elevated the RB% of verapamil by 1.26- to 1.69-fold.”
“In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil.”
“ Naringin pretreatment significantly altered the pharmacokinetic parameters of verapamil.”
“the MR of verapamil were significantly (p<0.05) increased in the pretreatment of naringin , implying that pretreatment of naringin may effectively inhibit the CYP3A4-mediated metabolism of verapamil.”
Effect of naringin pretreatment on bioavailability of verapamil in rabbits“The above data suggested that the metabolism of verapamil and the formation of norverapamil was inhibited by naringin possibly by inhibition of CYP3A in rabbits.”
“With naringin , the AUC of verapamil was significantly greater (28.4 versus 18.4 microg min/ml).”
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