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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Verapamil and Glabridin

supplement:

Glabridin

Research Papers that Mention the Interaction

Addition of verapamil in both apical (AP) and basolateral (BL) sides abolished the polarized transport of glabridin across Caco-2 cells.
Incubation of verapamil significantly altered the intracellular accumulation and efflux of glabridin in Caco-2 cells.
The systemic bioavailability of glabridin was approximately 7.5% in rats, but increased when combined with verapamil.
Drug Metabolism and Disposition  •  2007  |  View Paper
On the other hand, GBD can downregulate the activity of P‐gp ATPase when cotreated with DOX or verapamil , revealing that GBD was a substrate of P‐gp.
European journal of pharmacology  •  2019  |  View Paper