“Combination of genistein (GT) and verapamil , a P-glycoprotein (P-gp) inhibitor, can increase GT absorption in situ perfusion technology in rat.”
“Our data show that verapamil would increase intestinal absorption of GT in rat, suggesting there is some drug–nutrition interaction between verapamil and GT.”
“The coadministration of verapamil (30.0 mg/kg) with GT caused a significant increase of the maximum GT plasma concentration (1.31-fold vs. GT, P < 0.05) and area under the curve (1.39-fold vs. GT, P < 0.05).”