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Last Updated: 2 years ago

Possible Interaction: Verapamil and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

Combination of genistein (GT) and verapamil , a P-glycoprotein (P-gp) inhibitor, can increase GT absorption in situ perfusion technology in rat.
Our data show that verapamil would increase intestinal absorption of GT in rat, suggesting there is some drug–nutrition interaction between verapamil and GT.
The coadministration of verapamil (30.0 mg/kg) with GT caused a significant increase of the maximum GT plasma concentration (1.31-fold vs. GT, P < 0.05) and area under the curve (1.39-fold vs. GT, P < 0.05).
European Journal of Drug Metabolism and Pharmacokinetics  •  2015  |  View Paper
Ka was increased obviously when verapamil was coper-fused with genistein (P < 0.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica  •  2008  |  View Paper
The effects of genistein and phenylarsine oxide on agonist-induced contractions were also observed in the presence of verapamil (10 microM).
Pulmonary pharmacology  •  1996  |  View Paper
It is concluded that genistein strongly affects the membranes, and the effect of genistein in canceling the activity of verapamil is discussed.
Journal of plant physiology  •  2009  |  View Paper