Possible Interaction: Verapamil and Calcium Supplement

“Our research showed that the stimulating effect of calcium on gastric acid secretion can be antagonized by verapamil administration, which reduces gastric acid secretion .”

“Blood pressure was not significantly altered in any treatment phase, although calcium tended to increase mean arterial pressure and verapamil abolished this effect.”

“In rats, verapamil decreases intestinal absorption of calcium , increases serum parathyroid hormone (PTH), and induces osteopenia.”

“ Supplemental calcium added to citrated platelet-rich plasma reversed both verapamil and diltiazem-induced inhibition of platelet aggregation.”

“When, after 46 min, the infusion of calcium was discontinued, the dilator response to verapamil increased to reach a level 53% higher than the initial control (n = 8; P less than 0.02).”

“ Verapamil is the prototype of those … selectively inhibit membrane transport of calcium , an action which accounts for the drug’s peripheral and coronary vasodilator properties, its effect on excitation-contraction coupling … hence its negative inotropic propensity, as well as its depressant effects on the sinus node and atrioventricular conduction.”

“These positive inotropic effects were converted to negative inotropic effects in the additional presence of the L-type Ca2+ channel blocker verapamil.”

“Based on the observation that several viruses induce cell death and progeny release by disrupting intracellular calcium homeostasis, we hypothesized that the alteration in intracellular calcium concentration induced by verapamil could improve the rate of virus release and spread, eventually enhancing the antitumoral activity of oncolytic adenoviruses.”

“However, verapamil may produce an increased L-type Ca2+ channel current (ICa,L) that may reinforce Ca2+ overload thereby promoting AF in the atrium.”

“Addition of charybdotoxin or verapamil blocked these K+ channels and inhibited Ca2+ -induced differentiation, as assessed by cornified envelope formation or transglutaminase activity.”