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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Verapamil
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The rate of cAMP formation was greater after ACTH plus verapamil treatment than after ACTH treatment alone, whereas A23187 inhibited ACTH-stimulated cAMP secretion to basal levels.”
The role of calcium in steroidogenesis in fetal zone cells of the human fetal adrenal gland.“ Verapamil (10 mumols/l) also inhibited the increase in … by collagenase-dispersed zona glomerulosa cells stimulated by ACTH (100 fmol to 100 nmol/l), angiotensin II (100 pmol to 10 nmol/l) and potassium (… and 8.4 mmol/l); stimulated corticosterone secretion was unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)”
Specific effects of agonists of the calcium messenger system on secretion of 'late-pathway' steroid products by intact tissue and dispersed cells of the rat adrenal zona glomerulosa.“At the higher dose (10(-4) M), verapamil totally inhibited the stimulation of corticosterone and aldosterone production induced by ACTH.”
“The Ca2+ antagonist verapamil (10(-6) to 10(-4) mol/liter) decreased basal aldosterone secretion as well as the response to angiotensin II, ACTH , and K+.”
“Increasing concentrations of verapamil caused an increase in th ACTH concentration required for half-maximal stimulation as well as a reduction in the maximum production of aldosterone.”
“3) Verapamil markedly inhibited either corticoidogenesis or Ca2+-influx in response to ACTH.”
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