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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Vasodilator Agents and Polyphenols

Research Papers that Mention the Interaction

These studies have indicated … antioxidant effects, plant polyphenols (… vasodilating factors [nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF) and prostacyclin] and inhibit the synthesis of vasoconstrictor endothelin-1 in endothelial … major pro-angiogenic factors, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in smooth muscle cells.
European journal of pharmacology  •  2004  |  View Paper
These findings show a good correlation between the concentration of polyphenols (especially kaempferol) of Spanish red wines and the vasodilatory effect , which may confer on them unique features in the prevention of cardiovascular disease.
European journal of pharmacology  •  2005  |  View Paper