Possible Interaction: Vasodilator Agents and Digitalis

“Moreover, digitalis has been shown to improve hemodynamics when added to other drugs including diuretics, ACE inhibitors and vasodilators.”

“The competition between digitalis and vasodilator therapy is now very apparent in some situations; however, the choice between these two groups of drugs (as treatment of first intention or in association) has to be carefully considered in each individual case.”

“The combination DIG plus CPT provoked a decrease in LVFP greater than that achieved … from that obtained with DIG or CPT.The results obtained by the combination of digitalis … vasodilator with a pronounced effect on the resistance vessels, such as … ventricular emptying, thus leading to an improved cardiac output.”

“Patients were treated beside digitalis and/or diuretics with vasodilators aggressively.”

“However, digitalis therapy in the long-term should be considered in conjunction with vasodilators or ACE inhibitors.”

“ Vasodilator treatment with long-activity nitrate derivatives intensifies the effects of treatment with digitalis and diuretics in left ventricular insufficiency.”

“These data may have clinical relevance to the concomitant use of vasodilators and digitalis in the treatment of congestive heart failure.”