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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Vasodilator Agents
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“This results in increase in cytosolic levels of calcium (Ca2+), which triggers the production and release of several vasodilator substances from these cells.”
Neurovascular unit dysfunction: A vascular component of Alzheimer disease?“It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms.”
“Due to an influence on the membrane potential they are important regulators of vascular tone by modulating endothelial calcium ions signaling and synthesis of vasodilating factors.”
“The calcium entry blocking actions of these drugs cause potent peripheral vasodilatory and antihypertensive effects in human subjects.”
“SummaryIntra-arterial infusions of Ca antagonistic vasodilator substances such as nifedipine (1–10 μg/min) and verapamil (30–100 μg/min) inhibited renal autoregulation in the perfused dog kidney.”
Abolition by calcium antagonists of the autoregulation of renal blood flow“The vasodilator effect of barbiturates is associated in part with inhibition of transmembrane influx of Ca++ ; the inhibition is more predominant on the influx evoked by KCl‐induced depolarization than by a stimulation of PGF2a receptors.”
“These results suggest that changes in intracellular concentrations of free Ca 2 + and sulfhydryl groups could influence the rate of formation of cyclic GMP by vasodilators and that this, in turn, could alter smooth muscle tone.”
“Thus, these two vasodilators appear to affect Ca++ utilization by different mechanisms and, presumably, in an additive manner.”
“In normal Tyrode's solution, all three vasodilators produced a shift to the right to the dose-response curve for calcium , the pA2 values being 5.90 for nifedipine, 4.88 for verapamil and 4.07 for diltiazem.”
“If it antagonises the effects of calcium ions, as has been suggested, then its powerful vasodilator action could result from interference with the role of calcium in generating action potentials or in the release of calcium ions during the initiation of muscle contraction.”
Statistics at square one. VII - statements of probability.
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