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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Vasodilator Agents and Calcium Supplement

Research Papers that Mention the Interaction

This results in increase in cytosolic levels of calcium (Ca2+), which triggers the production and release of several vasodilator substances from these cells.
Neurology  •  2007  |  View Paper
It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms.
American journal of hypertension  •  1991  |  View Paper
Due to an influence on the membrane potential they are important regulators of vascular tone by modulating endothelial calcium ions signaling and synthesis of vasodilating factors.
Pharmacological reports : PR  •  2006  |  View Paper
The calcium entry blocking actions of these drugs cause potent peripheral vasodilatory and antihypertensive effects in human subjects.
The American journal of medicine  •  1984  |  View Paper
SummaryIntra-arterial infusions of Ca antagonistic vasodilator substances such as nifedipine (1–10 μg/min) and verapamil (30–100 μg/min) inhibited renal autoregulation in the perfused dog kidney.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The vasodilator effect of barbiturates is associated in part with inhibition of transmembrane influx of Ca++ ; the inhibition is more predominant on the influx evoked by KCl‐induced depolarization than by a stimulation of PGF2a receptors.
Acta anaesthesiologica Scandinavica  •  1990  |  View Paper
These results suggest that changes in intracellular concentrations of free Ca 2 + and sulfhydryl groups could influence the rate of formation of cyclic GMP by vasodilators and that this, in turn, could alter smooth muscle tone.
Biochemical pharmacology  •  1980  |  View Paper
Thus, these two vasodilators appear to affect Ca++ utilization by different mechanisms and, presumably, in an additive manner.
The Journal of pharmacology and experimental therapeutics  •  1979  |  View Paper
In normal Tyrode's solution, all three vasodilators produced a shift to the right to the dose-response curve for calcium , the pA2 values being 5.90 for nifedipine, 4.88 for verapamil and 4.07 for diltiazem.
Japanese journal of pharmacology  •  1977  |  View Paper
If it antagonises the effects of calcium ions, as has been suggested, then its powerful vasodilator action could result from interference with the role of calcium in generating action potentials or in the release of calcium ions during the initiation of muscle contraction.
British medical journal  •  1976  |  View Paper