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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Adjunctive therapies, such as hydrocortisone, thiamine, and ascorbic acid , may increase BP in severe shock and should be considered when combination vasopressor therapy is needed.”
Management of Refractory Vasodilatory Shock“Recent small controlled studies using pharmacological doses (6–16 g/day) suggest that vitamin C reduces vasopressor support and organ dysfunction, and may even decrease mortality.”
“Local administration of ascorbic acid (Asc) at a supraphysiological concentration inhibits the cutaneous vasoconstrictor response to local cooling (LC).”
“These findings suggest that oral Asc acutely enhances the cutaneous vasoconstrictor responses to LC through the modification of adrenergic sympathetic mechanisms.”
“Coadministration of vitamin C completely restored the potency of vasoconstrictors to that in controls but had no effect in healthy subjects.”
“… vitamin C was not associated with a significantly lower … associated with a significantly shorter duration of vasopressor use (standardized mean difference, -0.35; 95% CI, -0.63 to -0.07; p < 0.01; I2 = … difference, -0.20; 95% CI, -0.32 to -0.08; p < 0.01; I2 = 16%).”
Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.“This meta-analysis demonstrated that the use of vitamin C (compared with placebo) led to a reduction in ICU mortality and a reduction in the dose of vasopressors in patients with septic shock.”
“ AA was associated with a decreased duration of vasopressor support and mechanical ventilation, but did not influence fluid requirement or urine output during the first 24 h of admission.”
“… vitamin C … vasopressor support (standardized mean difference −0.71; 95% confidence interval (−1.16 to −0.26); p = 0.002) and decreased duration of mechanical ventilation (standardized …), but no difference was found in mortality (odds ratio 0.76; 95% confidence interval (0.27 to 2.16); p = 0.6).”
“ Ascorbic acid attenuated the pressor response to voluntary apnea (ΔMAP: 6 ± 2 mmHg) as compared to saline (ΔMAP: 12 ± 2 mmHg, P = 0.034) and also attenuated forearm vasoconstriction (ΔBBFV: 4 ± 9 vs. −12 ± 7%, P = 0.049) but did not affect ΔHR.”
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