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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Vancomycin
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Intravenous high dose VC can significantly reduce the nephrotoxicity of vancomycin and shorten the length of hospital stay.”
[High dose vitamin C significantly reduces the nephrotoxicity of vancomycin in critically ill patients].“Co-treatment with 0.5 and 1 mM VC attenuated 4-8 mM VCM induced cell death and increased the cell viability to 58-90%.”
Vitamin C attenuates vancomycin induced nephrotoxicity through the reduction of oxidative stress and inflammation in HK-2 cells.“Vancomycin was intraperitoneally injected into mice once daily for 7 d. Additionally, high-dose VC was intraperitoneally injected into … at 30 min before vancomycin administration for 7 d. The plasma creatinine and urea nitrogen levels were increased by vancomycin treatment; however, …-dose VC preadministration suppressed the … in these levels.”
“Vitamin E, vitamin C , N-acetylcysteine and CAPE administrations decreased the blood urea nitrogen levels increased by vancomycin , although significant differences were detected only in the vitamins E and C groups (P < 0.05).”
“Conclusion Co-administration of ascorbic acid with vancomycin preserved renal function and reduced the absolute risk of VAN by 20.3%, however, the reduction in VAN incidence didn’t reach statistical significance level.”
Impact of ascorbic acid in reducing the incidence of vancomycin associated nephrotoxicity in critically ill patients: A preliminary randomized controlled trial
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