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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Valproic Acid
supplement:
Vitamin D
Research Papers that Mention the Interaction
“Administration of a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception resulted in significantly reduced calcium and vitamin D levels in study 1 compared with the control groups (P < 0.001).”
Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats.“Cumulative meta-analysis showed progressive negative effect of valproate therapy on Vit D levels across time.”
“Patients with the CC genotype had lower adjusted plasma VPA concentrations than those with CT or TT genotype (P = 0.028).”
“AEDs, including valproic acid , are known to decrease 25-hydroxyvitamin D levels.2 It has been reported that babies born to women taking AEDs during pregnancy had significantly lower 25-hydroxyvitamin D concentrations compared to healthy control newborns.3 Vitamin …”
“Furthermore, cholecalciferol (at its highest subthreshold dose of 18.75 mug) potentiated the anticonvulsant activity of phenytoin and valproate.”
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.“Our data indicate that VPA may modulate the differential expression of proteins involved in mitochondrial function and vitamin D receptor-mediated chromatin transcriptional regulation and proteins implicated in the pathogenesis of neurodegenerative diseases.”
Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells“Amongst antiepileptic drugs, carbamazepine and sodium valproate were significantly associated with 25-hydroxyvitamin D deficiency.”
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