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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Valproic Acid
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“Phenobarbital (PB), midazolam, diazepam, sodium valproate VPA ), and pyridoxal were ineffective.”
Epileptic encephalopathy patients with SCN2A variant initiated by neonatal seizure“Then, we added a smaller dose of VB6 to VPA.”
“Several studies have reported that valproic acid therapy lowers vitamin B6 levels.”
“The combination therapy of vitamin B6 and VPA was effective in 58.3% of the patients with symptomatic WS.”
“The group which had valproic acid added to vitamin B6 therapy had significantly fewer seizures (P less than 0.05) and better electroencephalograms (P less than 0.01) than did the group treated initially with vitamin B6 alone.”
“ VPA induced a 56% reduction in methionine adenosyltransferase activity and a 54% reduction in plasma vitamin B-6.”
Acute valproate administration impairs methionine metabolism in rats.“b) Valproic acid reverses the effect of PLP on ethanolamine and choline incorporation into cell lipid.”
Effect of pyridoxal 5'-phosphate and valproic acid on phospholipid synthesis in neuroblastoma NA.
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