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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Valproic Acid
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“In adults and children the use of valproic acid was found to correlate with a higher vitamin B12 level.”
[The use of anticonvulsants and the levels of folate, vitamin B12 and homocysteine].“ Vitamin B12 levels were elevated and glucose reduced in children treated with VPA.”
“On the other hand, the administration of a mean daily dose of 2070mg of VPA resulted in a 57% increase in plasma Vitamin B-12 concentrations over the baseline value and a 27% decline in plasma tHcy concentrations, although the mechanisms of such changes are unknown.”
“ Valproate administration increased serum vitamin B-12 concentrations.”
“Both FA and vitamin B12 concentrations were reduced by VPA , HC and HC + VPA, but HC and VPA when combined did not produce an additive effect on vitamin levels.”
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos“This atypical presentation could be due to concurrent use of valproate and low serum vitamin B12 levels.”
Unilateral tremor induced by risperidone in a patient with acute mania: Vitamin B12 deficiency as possible mediating factor
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