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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Valproic Acid
supplement:
Medium Chain Fatty Acid
Research Papers that Mention the Interaction
“In the inhibitory experiments, some short-chain fatty acids, such as acetic acid, lactic acid, propanoic acid and butyric acid, and medium-chain fatty acids , such as hexanoic acid and octanoic acid, inhibited the uptake of [3H]valproic acid.”
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).“Short-chain monocarboxylates such as propionic acid, pyruvic acid, and L-lactic acid did not alter the vessel/medium ratio, whereas medium-chain fatty acids and unsaturated metabolites of VPA significantly inhibited the net transport of VPA.”
Mechanism of valproic acid uptake by isolated rat brain microvessels
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