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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Valproic Acid
supplement:
Levomefolate
Research Papers that Mention the Interaction
“… VPA interferes with … of methylfolate into the brain and the placenta by targeting folate receptors; 2) that VPA effects on the folate metabolic system contribute to congenital … exposure; and 3) that genetic factors, notably polymorphisms related to one-carbon metabolism, contribute to the vulnerability to these VPA-induced risks.”
Valproate and folate: Congenital and developmental risks“ Valproate exposure was also associated with an increase in 5-methyl-tetrahydrofolate (THF) (p=0.002) and a decrease in 5-10-methenyl-THF in the brain of newborn pups, as well as a reduced homocysteine plasma level (p<0.001).”
Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity
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