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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Valproic Acid
supplement:
Docosahexaenoic Acid
Research Papers that Mention the Interaction
“ DHA treatment significantly increased DHA (1.4±0.2 vs. 4.1±0.5%) and DPA (2.0±0.4 vs. 3.0±0.4%) concentrations, but not EPA.”
EPA, but not DHA, decreases mean platelet volume in normal subjects“The n-3 fatty acid docosapentaenoic acid DPA , 22 : 5n-3) was in excess of DHA (22 : 6n-3).”
“… DHA … VPA (1) prevented VPA-induced learning and memory impairment but did not change social-related behavior, (2) increased total DHA content in offspring plasma and … the activity of caspase-3 in offspring hippocampus and (6) enhanced relative levels of p-CaMKII and p-CREB proteins in the hippocampus.”
Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid.“Retention of DPA (22:5n-3) was high at low levels of DHA, but diminished with increasing DHA inclusion, similar to that seen with DHA retention.”
“These results suggested that DPA retroconverted to AA, blunting the decrease in AA content caused by DHA administration.”
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