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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Valproic Acid
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Administration of a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception resulted in significantly reduced calcium and vitamin D levels in study 1 compared with the control groups (P < 0.001).”
Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats.“In dogs given calcium valproate at 100, 200 and 400 mg/kg for 13 weeks, testicular atrophy was seen at 400 mg/kg and mild hepatocellular changes at all doses.”
“In rats given calcium valproate at 125, 250 and 500 mg/kg for 1 year, reduced plasma protein and globulin levels and a dose-dependent increased incidence and severity of atrophic pancreatitis were noted at 250 and 500 mg/kg.”
“By comparison, valproate interferes with both calcium and sodium ion influx, and influences both GABA and glutamate (Stahl, 2000).”
“ Valproate showed a dose-dependent attenuation of agonist-induced intracellular Ca rise, both in the absence and presence of ML-9.”
“A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found.”
“CBZ, PHT, and VPA , but not lamotrigine (LTG), are associated with lower levels of calcium.”
“Ethosuximide and possibly VPA reduce a low‐threshold calcium current.”
“Compounds such as carbamazepine, phenytoin, and probably valproate act by modifying ionic conductances, particularly sodium and calcium , in excitable membranes, thus limiting sustained high‐frequency neuronal discharges.”
“Serum concentrations of calcium were significantly higher with VPA than in PHT or control groups.”
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