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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Valproic Acid and Alpha-Ketoglutarate

Research Papers that Mention the Interaction

Searching for the mechanism of action, we found that VPA decreased the level of alpha-ketoglutarate (alpha-KG; a cofactor of butyrobetaine hydroxylase) from 73.5 +/- 2.90 nmol/g to 52.9 +/- 2.2 nmol/g (mean +/- SEM) in the liver.
Biochemical pharmacology  •  1996  |  View Paper
While the pyruvate and 2-oxoglutarate oxidation rates of rat … nearly unaffected by VPA, rat liver mitochondrial pyruvate and 2-oxoglutarate oxidation was … VPA concentrations above 100 µM. Among the reactions involved in pyruvate oxidation, pyruvate transport … were not affected by VPA, while α-lipoamide dehydrogenase was strongly inhibited.
International journal of molecular sciences  •  2017  |  View Paper
VPA (0.1-1.0 mM) was found to inhibit oxygen consumption and ATP synthesis under state 3 conditions with glutamate and 2-oxoglutarate as respiratory substrates.
Biochimica et biophysica acta  •  2007  |  View Paper
Rat liver mitochondria incubated with valproate displayed time-dependent inhibitions of state 3 oxidation rates with all the substrates tested, but most markedly with glutamate, pyruvate, alpha-ketoglutarate and acylcarnitines (Ki = 125 microM with glutamate and palmitoylcarnitine, and 24 microM with pyruvate).
Biochemical pharmacology  •  1990  |  View Paper
Valproate strikingly reduced the renal cortical concentrations of glutamine, glutamate, alphaketoglutarate and citrate, and more modestly those of malate, oxaloacetate, aspartate, alanine and ATP.
Kidney international  •  1988  |  View Paper