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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Valproic Acid
supplement:
4-Hydroxybutyric Acid
Research Papers that Mention the Interaction
“Furthermore, valproate seems to reduce the release of the epileptogenic amino acid gamma-hydroxybutyric acid and to block cell firing induced by NMDA-type glutamate receptors.”
Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain“Furthermore, valproate seems to reduce the release of the epileptogenic amino acid gamma-hydroxybutyric acid and to attenuate neuronal excitation induced by NMDA-type glutamate receptors.”
“The rate of GHB synthesis was estimated from the increase in GHB levels after inhibition of its catabolism with valproate.”
Experimental absence seizures: potential role of gamma-hydroxybutyric acid and GABAB receptors.“Using the antiepileptic drug, valproate which strongly inhibits gamma-hydroxybutyric acid release and degradation, we estimated the turnover rate of this compound in six regions of the rat brain.”
Gamma hydroxybutyrate distribution and turnover rates in discrete brain regions of the rat
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