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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin A
Research Papers that Mention the Interaction
“A significant dose-dependent inhibition of uPA activity was observed after treatment with retinol , while no significant effect was detected upon tPA secretion.”
“Moreover, retinol affected uPA mRNA levels by increasing mRNA turnover.”
“The analysis of the mRNA levels revealed that retinol induces an inhibition of the steady-state levels of uPA mRNA without affecting those of tPA.”
“When Sertoli cells were cultured in the presence of 0.25 μM retinol , a significant inhibition of uPA activity was evident after 16 h of treatment and reached approximately 80% after 48 h of treatment.”
Retinoid Modulation of Plasminogen Activator Production in Rat Sertoli Cells1“Insulin also stimulated uPa and tPa production by prepubertal Sertoli cells, and retinol significantly suppressed uPa production and the ability of FSH to stimulate tPa production by midpubertal Sertoli cells.”
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