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“The western blot analysis indicated that PEITC decreased the levels of proteins associated with migration and invasion, Ras, uPA , RhoA, GRB2, p-p38, p-JNK, p-ERK, p65, SOS1, MMP-2, MMP-9 and MMP-13, in a dose-dependent manner.”
“… PEITC exerted an inhibitory effect on the ERK1/2, mitogen-activated protein kinase kinase 7 (… sevenless 1 (SOS1), PKC, Ras homolog gene family, member A (Rho A) and urokinase-type plasminogen activator (uPA), causing the inhibition of matrix metallopeptidase-2 (MMP-… invasion and migration of GAS cells in vitro.”