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Last Updated: 2 years ago

Possible Interaction: Urokinase-Type Plasminogen Activator and Genistein

Research Papers that Mention the Interaction

Genistein inhibited uPA secreted by F3II cell monolayers, while inducing an increase in the proteolytic activity of B16 cells.
Oncology reports  •  2006  |  View Paper
Genistein exhibited a dose-dependent inhibition of expression/excretion of vascular endothelial growth factor165, platelet-derived growth factor, tissue factor, urokinase plasminogen activator , and matrix metalloprotease-2 and 9, respectively.
Biochemical pharmacology  •  2005  |  View Paper
The effect of urokinase was completely suppressed by genistein and by herbimycin A indicating that tyrosine kinase(s) are required for MMP9 production.
Journal of Vascular Research  •  2006  |  View Paper
Here we demonstrate that genistein suppresses cell adhesion and migration by inhibiting the constitutively active transcription factors NF-kappaB and AP-1, resulting in the suppression of secretion of urokinase-type plasminogen activator (uPA) in breast cancer cells MDA-MB-231.
However, only genistein and daidzein inhibited constitutively active NF-kappaB and AP-1 and suppressed secretion of uPA from breast cancer cells.
International journal of oncology  •  2004  |  View Paper
The alphavbeta6 correlated increase in HMW-uPA and pro-MMP secretion could be inhibited by tyrosine kinase inhibitor genistein or the MEK 1 inhibitor U0126, consistent with a role of active p42/44 MAPK in the elevation of uPA, MMP-9, and MMP-2 secretion.
Journal of cellular biochemistry  •  2002  |  View Paper
Genistein attenuated uPA activity and stimulated PAI activity in both cell lines, leading to a decrease in the PA/PAI ratio.
European journal of cancer  •  1998  |  View Paper
However, genistein suppressed the growth stimulatory effect of growth factors on HCE 16/3 cells and also reduced KGF-enhanced uPA secretion in this cell line.
Zhonghua zhong liu za zhi [Chinese journal of oncology]  •  1997  |  View Paper
Genistein , a specific tyrosine kinase inhibitor, reduced the constitutive and staurosporine‐induced uPA and MMP‐9 secretion.
International journal of cancer  •  1998  |  View Paper