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“The coordination of Cu(II) ions to tau immobilized on gold surfaces induces an electrochemical signal at approximately 140±5mV versus Ag/AgCl due to the Cu(II)/Cu(I) redox couple.”
“There is increasing evidence that the Cu(II) ion may play an important role in tau biochemistry.”
“According to circular dichroism and NMR spectroscopy, Tau remains largely disordered upon binding to Cu(II) , although a limited amount of aggregation is induced.”