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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Urea
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“Furthermore, concentrations in plasma of proline and histidine, precursors of glutamate biosynthesis, are increased; inorganic phosphate and urea are significantly decreased in hemodialysis patients after 1 year of calcium alpha-ketoglutarate administration.”
Calcium alpha-ketoglutarate administration to malnourished hemodialysis patients improves plasma arginine concentrations.“In the lactating sows, dietary supplementation of AKG decreased plasma urea level on d 14 of lactation, decreased plasma calcium (Ca) concentrations from d 7 to d 21 of lactation and increased lactose and Ca levels in ordinary milk.”
Effects of maternal alpha-ketoglutarate supplementation during lactation on the performance of lactating sows and suckling piglets“The alpha-keto analogues of the branched-chain amino acids, and particularly that of leucine, alpha-ketoisocaproate (KIC), have been found to reduce urea synthesis and as a result have been proposed for the treatment of uremia and portal systemic encephalopathy.”
“ Urea above 1M being in reaction mixture inhibits constitutive GDH in a competitive manner to L-glutamate and uncompetitively regards to alpha-oxoglutarate.”
[Effect of dissociating agents on Chlorella glutamate dehydrogenases].
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