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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“ Folate plays a critical role in the prevention of uracil incorporation into DNA and hypomethylation of DNA.”
Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity.“Because of their metabolic function, folate and other one-carbon micronutrients may be important factors in the control of uracil misincorporation.”
“ Folate supplementation elicited a significant reduction in uracil misincorporation (P<0.05), while DNA strand breakage and global DNA methylation remained unchanged.”
“A low folate status can induce misincorporation of uracil into DNA, leading to chromosome breaks”
“ Folate deficiency significantly increases uracil content and chromosome breaks (as measured by micronucleated cells) in human leukocyte DNA.”
“Folate supplementation reduces both the uracil content of DNA and the frequency of micronucleated cells, indicating that uracil misincorporation may play a causative role in folate deficiency-induced chromosome breaks.”
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